Particle engineering is of crucial relevance for the production of oral forms of poorly soluble drugs, as proven by the micronized and more recently nanosized formulations which have been marketed.
A fine and tunable control of particle size and morphology is also required for the development of inhalable drugs, injectable suspension, combination therapies and challenging drugs with a narrow therapeutic index.
Nevertheless, tailored and differentiated drug particles with low solvent residues can be difficult to produce in a reliable way by currently available techniques such as crystallization or milling, thus hindering the development of new chemical entities and enhanced formulations of off-patent drugs.
Some applications of our supercritical fluid technology platform for particle engineering :
- Tailored particles for inhaled therapy
- Polymorph screening
- Improved bioavailability of poorly soluble drugs
- Stabilization and sustained-release delivery of biopharmaceuticals
- Solid dispersion microparticles